Customer facing challenges getting desired multiplex editing result, and wanted to investigate the cause.
CRISPR-Chip™ analysis was used to characterize the binding kinetics of different gRNAs to Cas.
CRISPR QC™ determined how different gRNAs compete for Cas binding sites. In this study, gRNA #5 proved to be the fastest displacer.
Insight provided by CRISPR QC™ has given the customer new factors to optimize their multiplex editing.
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